Molecular phenotypes, or subtypes, can describe cancer as distinct diseases within primary tissues-of-origin. Machine learning (ML) can be applied to this molecular taxon [...]

This report on programmatic assessment at OHSU summarizes the work of the last academic year 2022-2023.

This report on programmatic assessment at OHSU summarizes the work of the last academic year 2023-2024.

This thesis examines MR1T cells and gamma-delta T cells in early life and how they are shaped by BCG vaccination with the goal of informing how they might be positioned f [...]

Adolescent social isolation is a developmental stressor that increases vulnerability to neuropsychiatric disorders including substance use disorder and eating disorders. [...]

Electronic health records (EHRs) provide a voluminous amount of data for research. However, potential biases threaten the internal and external validity of observational [...]

My research investigates how components of the contact activation system regulate endothelial function. First, I characterized the molecular mechanism of prekallikrein (P [...]

Acute myeloid leukemia (AML) is a malignancy with a poor survival rate, primarily due to resistance to chemotherapy.Combination therapy using gilteritinib with venetocla [...]

MYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular [...]

This dissertation uncovers how PARP7 regulates transcription and innate immune signaling, with a focus on its suppression of type I interferon (IFN-I) expression. It iden [...]