Department of Molecular and Medical Genetics

The goal of this dissertation is to improve our understanding of the factors governing genetic repair to facilitate whole gene insertion into the genome of mature organis [...]

Current treatments for FTD mitigate some behavioral changes, but there are no therapies that prevent or slow the progression of the disease. Profiling the epigenetic chan [...]

Pancreatic Ductal Adenocarcinoma (PDAc) ranks among the top three most aggressive cancers in the United States and is projected to increase in incidence over the next few [...]

The goal of this dissertation is to improve understanding and treatment for the chorioretinopathy seen in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) p [...]

Liver-directed gene and cell therapies represent a promising therapeutic strategy for many genetic disorders. However, they are hampered by inefficiency. The problem of i [...]

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective [...]

Single-cell technologies have created a new taxonomic challenge: to create a shared language for defining individual cells within complex organisms. In this work, I compl [...]

The loss and/or gain of whole chromosomes, or aneuploidy, that arises during mammalian preimplantation development can lead to embryo arrest, implantation failure, or spo [...]

Ovarian teratoma, comprising cystic mature teratomas and malignant immature teratomas, is a common cancer of the female reproductive tract that tends to occur in young wo [...]

Normal placentation is essential for the health and well-being of both the mother and fetus throughout pregnancy. In humans, defective placental development contributes t [...]