Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin angiotensin system (RAS) that acts by degrading angiotensin II (AngII). Within the kidney, ACE2 is [...]

Malaria is a mosquito-borne parasitic disease that has deeply impacted the human population throughout recorded history. The disease burden of malaria has gradually decli [...]

Sympathetic nerves are lost in the damaged myocardium (infarct) after myocardial infarction (MI), and the relative area of denervation predicts risk of sudden cardiac arr [...]

Obesity increases both the incidence and severity of asthma, but the underlying mechanisms leading to the development of obesity-related asthma remain elusive. High insul [...]

Technological changes to modern society have lead to circadian misalignment in a significant portion of the population, resulting in numerous metabolic, sleep, [...]

Illness behaviors, metabolic disturbances, and cognitive injury are common in cancer patients and frequently lead to wasting or cachexia. This devastating state of malnut [...]

The human heart starts beating at 21 days gestation and does not stop until death. This posits an incessant metabolic demand that must be met despite abrupt changes to ca [...]

This dissertation describes the development of the TRADE system for directed evolution of the AAV capsid, its successful application to identify the HN1 variant, a novel [...]

The assays developed in this thesis research also offer a path to address some remaining gaps in our knowledge such as substrate assisted gate closure and the substrate r [...]

The medial olivocochlear (MOC) system aids in the prevention of age- and noise-induced hearing loss, and enhances the detection of salient sound in diverse sensory enviro [...]