Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important in the early response to bacterial and viral lung pathogens. Upon activation, MAIT [...]

This work explores immunity induced by the yellow fever vaccine, 17D, efficacy. First, we provide a comprehensive review of breakthrough yellow fever infection. Next, we [...]

In this dissertation I explore applications of antibodies and alpaca-derived antibody fragments, known as VHHs, to understand severe acute respiratory associated coronavi [...]

Tuberculosis (TB) is a devastating illness. In the search for novel anti-TB therapies, there is growing interest in host-directed therapy (HDT), which seeks to synergize [...]

Dendritic cells (DCs) play a crucial role in mediating immune responses to pathogens and tumors, with their development influenced by signaling from the FLT3 receptor tyr [...]

While it is becoming more appreciated that non-hematopoietic cells within barrier tissues participate in and modulate the host immune response, their roles are still inco [...]

Here, I present a comprehensive assay termed UbiReal for monitoring each step of the Ub signaling cascade, including linkage-specific polyUb ligation and deubiquitination [...]

Interferon (IFN) family cytokines stimulate a broad group of genes known as interferon stimulated gene (ISGs). The primary function of ISGs is to provide antiviral host d [...]

In the absence of a prophylactic vaccine and curative strategies, the daily use of antiretroviral therapy (ART) is essential for preventing and maintaining HIV infection. [...]

Monoclonal antibodies targeting key receptors that inhibit T cell function such as CTLA-4 and PD-1 have demonstrated the potency of checkpoint blockade, highlighted by lo [...]