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Abstract

Approximately one million individuals with temporomandibular joint (TMJ) disorders experience advanced symptoms, such as disc perforations, necessitating the removal of the articular disc (AD). The TMJ AD is defined as fibrocartilage residing between the skull and jaw bones. The goals of my work were to study the developmental origin of the tissue defined as the AD, and to identify and use an appropriate cell source for TE of the AD. My results indicate a tenogenic origin of the AD that is not the current classification of the AD tissue. Furthermore, I was able to characterize and engineer tissue with a cloneable population of progenitor cells isolated from the AD itself. These results could have major impacts on the tissue engineering and clinical approaches to TMJ tissue regeneration.

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