Dengue virus and the suppression of the cellular innate immune response: antiviral microRNAs as a tool for probing host-virus interactions
Murphy, Ashleigh R.
2017

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Abstract

This dissertation describes the implementation of a technique for using cellular miRNAs as tools for the discovery of virus-host interactions. With this methodology, I discovered a new function for the UPR during DENV2, namely inhibition of innate immune signaling, as well as identifying a miRNA that impedes flavivirus infection in spite of failure to enhance cellular immunity.

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Title Dengue virus and the suppression of the cellular innate immune response: antiviral microRNAs as a tool for probing host-virus interactions
Creator Murphy, Ashleigh R.
Publisher Oregon Health and Science University
Date 2017
Subjects
Keywords
DOI https://doi.org/10.6083/m4sx6csd
Content Type Dissertation
Degree Type Ph.D.
Department Department of Molecular Microbiology and Immunology
School School of Medicine
Copyright Status
Record ID 7666
Record Created 2023-06-29
Record Appears in Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Molecular Microbiology and Immunology
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
OHSU Works > Student Work > Dissertations
Theses and Dissertations
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