This paper describes the formative evaluation of a naloxone program at a center for integrative health. The aim of this project was a small part of a larger, nationwide effort to mitigate opioid overdose death fatalities. The scope of the opioid epidemic is growing and current literature supporting the efficacy of naloxone and opioid overdose prevention programs highlights the need for widespread collaboration in addressing this problem. The clinical project involved initiating an opioid overdose prevention program to train staff in the outpatient clinic setting who work with high-risk populations. A repeated measures design was used to evaluate changes in staff self-efficacy, willingness to assist, and general knowledge and comprehension prior to and 30 days after undergoing opioid overdose management and naloxone training. Participants were found to have higher than expected levels of pre-existing knowledge and comprehension and showed post-training improvement in both self-efficacy and willingness to respond in an opioid overdose situation. Ultimately, the clinic established an opioid overdose prevention protocol by utilizing the guidance of the Oregon Health Authority, 35 staff members were successfully trained in opioid overdose recognition and treatment, and the clinic obtained multiple rescue doses of the opioid overdose reversal medication, naloxone, for on-site emergency utilization. This project successfully initiated training for clinic staff and helped to acquire access to naloxone; in this way, the clinic is now better able to safely serve its high-risk population. There are ongoing barriers with regards to widespread naloxone distribution and access. Moving forward, the national movement to mitigate opioid abuse/misuse and opioid-related deaths will require the support of public policies that support and implement widespread opioid overdose prevention and treatment education, increased access to and distribution of naloxone, and increased access to addiction treatment and medication-assisted treatment programs.