TY  - GEN
N2  - Multiple endocrine neoplasia (MEN) is a rare genetic condition that predisposes patients to developing endocrine tumors. The condition is autosomal dominant and is associated with several germline RET mutations including Cys618Ser. Virtually all patients with the untreated 2A variant of this condition (MEN2A) will develop medullary thyroid carcinoma (MTC), a malignancy with an estimated 5-year survival of 68-80%.  With the consequences of malignancy in untreated persons at a young age, further work to construct a more extensive pedigree would help to identify individuals who could benefit from genetic testing and subsequent prophylactic treatment.
DO  - 10.6083/c821gk45j
DO  - DOI
AB  - Multiple endocrine neoplasia (MEN) is a rare genetic condition that predisposes patients to developing endocrine tumors. The condition is autosomal dominant and is associated with several germline RET mutations including Cys618Ser. Virtually all patients with the untreated 2A variant of this condition (MEN2A) will develop medullary thyroid carcinoma (MTC), a malignancy with an estimated 5-year survival of 68-80%.  With the consequences of malignancy in untreated persons at a young age, further work to construct a more extensive pedigree would help to identify individuals who could benefit from genetic testing and subsequent prophylactic treatment.
AD  - Oregon Health and Science University
T1  - Genetic outreach for multiple endocrine neoplasia (MEN2A) in a Mexican immigrant cohort
ED  - Li, Ryan
ED  - Quintanilla-Diecks, Lourdes
ED  - Mentor
ED  - Co-PI
DA  - 2023
AU  - Jorizzo, Matt
L1  - https://digitalcollections.ohsu.edu/record/10035/files/Jorizzo.Matt.2023..pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023
ID  - 10035
L4  - https://digitalcollections.ohsu.edu/record/10035/files/Jorizzo.Matt.2023..pdf
KW  - Multiple Endocrine Neoplasia Type 2a
KW  - Emigrants and Immigrants
KW  - Hyperparathyroidism
KW  - Pedigree
KW  - Genetic Testing
KW  - Thyroidectomy
KW  - Adrenal Gland Neoplasms
KW  - mexican people
TI  - Genetic outreach for multiple endocrine neoplasia (MEN2A) in a Mexican immigrant cohort
Y1  - 2023
L2  - https://digitalcollections.ohsu.edu/record/10035/files/Jorizzo.Matt.2023..pdf
LK  - https://digitalcollections.ohsu.edu/record/10035/files/Jorizzo.Matt.2023..pdf
UR  - https://digitalcollections.ohsu.edu/record/10035/files/Jorizzo.Matt.2023..pdf
ER  -