000010035 001__ 10035
000010035 005__ 20240125143603.0
000010035 0247_ $$2DOI$$a10.6083/c821gk45j
000010035 037__ $$aIR
000010035 041__ $$aeng
000010035 245__ $$aGenetic outreach for multiple endocrine neoplasia (MEN2A) in a Mexican immigrant cohort
000010035 260__ $$bOregon Health and Science University
000010035 269__ $$a2023
000010035 336__ $$aCapstone
000010035 502__ $$gMedicine (Undergraduate Medical Education)
000010035 502__ $$bM.D.
000010035 520__ $$aMultiple endocrine neoplasia (MEN) is a rare genetic condition that predisposes patients to developing endocrine tumors. The condition is autosomal dominant and is associated with several germline RET mutations including Cys618Ser. Virtually all patients with the untreated 2A variant of this condition (MEN2A) will develop medullary thyroid carcinoma (MTC), a malignancy with an estimated 5-year survival of 68-80%.  With the consequences of malignancy in untreated persons at a young age, further work to construct a more extensive pedigree would help to identify individuals who could benefit from genetic testing and subsequent prophylactic treatment.
000010035 540__ $$fCC BY
000010035 542__ $$fIn copyright - single owner
000010035 650__ $$aMultiple Endocrine Neoplasia Type 2a$$031117
000010035 650__ $$aEmigrants and Immigrants$$037730
000010035 650__ $$aHyperparathyroidism$$020526
000010035 650__ $$aPedigree$$023690
000010035 650__ $$aGenetic Testing$$019469
000010035 650__ $$aThyroidectomy$$027072
000010035 650__ $$aAdrenal Gland Neoplasms$$014302
000010035 651__ $$aOregon$$041094
000010035 6531_ $$amexican people
000010035 691__ $$aSchool of Medicine$$041369
000010035 7001_ $$aJorizzo, Matt$$uOregon Health and Science University$$041354
000010035 7201_ $$aLi, Ryan$$uOregon Health and Science University$$041354$$eMentor$$7Personal
000010035 7201_ $$aQuintanilla-Diecks, Lourdes$$uOregon Health and Science University$$041354$$eCo-PI$$7Personal
000010035 8564_ $$9baaf9478-e241-4241-a43a-c22cfe53e2de$$s267437$$uhttps://digitalcollections.ohsu.edu/record/10035/files/Jorizzo.Matt.2023..pdf
000010035 905__ $$a/rest/prod/c8/21/gk/45/c821gk45j
000010035 909CO $$ooai:digitalcollections.ohsu.edu:10035$$pstudent-work
000010035 980__ $$aScholarly Project Capstones