000010077 001__ 10077
000010077 005__ 20240124114335.0
000010077 0247_ $$2DOI$$a10.6083/zk51vh59w
000010077 037__ $$aETD
000010077 245__ $$aClinical and research applications of circulating tumor DNA detection, monitoring, and dynamics in cancer patients
000010077 260__ $$bOregon Health and Science University
000010077 269__ $$a2023
000010077 336__ $$aDissertation
000010077 502__ $$bPh.D.
000010077 520__ $$aLiquid biopsy provides a minimally-invasive alternative to solid tissue biopsy for assessing tumor-derived molecules such as circulating tumor DNA (ctDNA). Detection and characterization of ctDNA in the blood shows promise in early cancer screening and diagnosis, and has prognostic value for risk-stratification at all stages of disease. ctDNA can also be used for minimally-invasive tumor genotyping, treatment monitoring, and pre-clinical detection of minimal residual disease and recurrence. Although once predicted as a panacea for these applications, the clinical implementation of ctDNA assays has met with significant technical hurdles. Moreover, poorly-understood biological mechanisms and a lack of standardized methods contribute to measurement variability. The work that follows is intended to (1) highlight the need for a deeper understanding of the biological underpinnings of ctDNA release and kinetics, and (2) test the limits of patient-specific and patient-agnostic ctDNA detection technologies in the clinical setting.
000010077 542__ $$fIn copyright - single owner
000010077 650__ $$aGenotype$$019486
000010077 650__ $$aCirculating Tumor DNA$$012292
000010077 650__ $$aBiopsy$$015582
000010077 6531_ $$aneoplasm
000010077 691__ $$aSchool of Medicine$$041369
000010077 692__ $$aDepartment of Biomedical Engineering$$041397
000010077 7001_ $$aBoniface, Christopher
000010077 8564_ $$9014edd23-1c06-44f3-bde5-a81a396118f3$$s11243300$$uhttps://digitalcollections.ohsu.edu/record/10077/files/Boniface.Christopher.2023.pdf
000010077 905__ $$a/rest/prod/zk/51/vh/59/zk51vh59w
000010077 909CO $$ooai:digitalcollections.ohsu.edu:10077$$pstudent-work
000010077 980__ $$aTheses and Dissertations