TY  - GEN
N2  - Systemic Lupus Erythematosus (SLE) is a chronic, multi-system autoimmune disorder that impacts 43.7 individuals per 100,000 people in the United States alone, with a higher prevalence of 78.83 cases per 100,000 in women. The exact pathogenesis and cause of SLE is poorly understood. Epstein-Barr Virus (EBV)-induced dysregulation of immune responses is one proposed mechanism for SLE pathogenesis. EBV encodes >44 viral microRNAs, which have been shown to manipulate several biological processes including immune responses. Data on which EBV miRNAs, if any, are upregulated in SLE patients can give mechanistic insight into the genes involved in SLE and how EBV contributes to the development of this disease. We performed secondary analysis on publicly-available SLE sequencing dataset for human and viral miRNAs, then expanded the analysis to include other autoimmune disorders.
DO  - 10.6083/t722h960p
DO  - DOI
AB  - Systemic Lupus Erythematosus (SLE) is a chronic, multi-system autoimmune disorder that impacts 43.7 individuals per 100,000 people in the United States alone, with a higher prevalence of 78.83 cases per 100,000 in women. The exact pathogenesis and cause of SLE is poorly understood. Epstein-Barr Virus (EBV)-induced dysregulation of immune responses is one proposed mechanism for SLE pathogenesis. EBV encodes >44 viral microRNAs, which have been shown to manipulate several biological processes including immune responses. Data on which EBV miRNAs, if any, are upregulated in SLE patients can give mechanistic insight into the genes involved in SLE and how EBV contributes to the development of this disease. We performed secondary analysis on publicly-available SLE sequencing dataset for human and viral miRNAs, then expanded the analysis to include other autoimmune disorders.
AD  - Oregon Health and Science University
T1  - Viral and human microRNA signatures in systemic lupus erythematosus and other autoimmune disorders
ED  - Chu, Cong-Qiu
ED  - Skalsky, Rebecca
ED  - Mentor
ED  - PI
DA  - 2023
AU  - Ivanov, Nikita
L1  - https://digitalcollections.ohsu.edu/record/10086/files/Ivanov.Nikita.2023.pdf
PB  - Oregon Health and Science University
PY  - 2023
ID  - 10086
L4  - https://digitalcollections.ohsu.edu/record/10086/files/Ivanov.Nikita.2023.pdf
KW  - Lupus Erythematosus, Systemic
KW  - Autoimmune Diseases
KW  - MicroRNAs
KW  - Epstein-Barr Virus Infections
KW  - sle
TI  - Viral and human microRNA signatures in systemic lupus erythematosus and other autoimmune disorders
Y1  - 2023
L2  - https://digitalcollections.ohsu.edu/record/10086/files/Ivanov.Nikita.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/10086/files/Ivanov.Nikita.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/10086/files/Ivanov.Nikita.2023.pdf
ER  -