000010086 001__ 10086
000010086 005__ 20240125143605.0
000010086 0247_ $$2DOI$$a10.6083/t722h960p
000010086 037__ $$aIR
000010086 245__ $$aViral and human microRNA signatures in systemic lupus erythematosus and other autoimmune disorders
000010086 260__ $$bOregon Health and Science University
000010086 269__ $$a2023
000010086 336__ $$aCapstone
000010086 502__ $$gMedicine (Undergraduate Medical Education)
000010086 502__ $$bM.D.
000010086 520__ $$aSystemic Lupus Erythematosus (SLE) is a chronic, multi-system autoimmune disorder that impacts 43.7 individuals per 100,000 people in the United States alone, with a higher prevalence of 78.83 cases per 100,000 in women. The exact pathogenesis and cause of SLE is poorly understood. Epstein-Barr Virus (EBV)-induced dysregulation of immune responses is one proposed mechanism for SLE pathogenesis. EBV encodes >44 viral microRNAs, which have been shown to manipulate several biological processes including immune responses. Data on which EBV miRNAs, if any, are upregulated in SLE patients can give mechanistic insight into the genes involved in SLE and how EBV contributes to the development of this disease. We performed secondary analysis on publicly-available SLE sequencing dataset for human and viral miRNAs, then expanded the analysis to include other autoimmune disorders.
000010086 540__ $$fCC BY
000010086 650__ $$aLupus Erythematosus, Systemic$$021656
000010086 650__ $$aAutoimmune Diseases$$015237
000010086 650__ $$aMicroRNAs$$034671
000010086 650__ $$aEpstein-Barr Virus Infections$$032072
000010086 6531_ $$asle
000010086 691__ $$aSchool of Medicine$$041369
000010086 7001_ $$aIvanov, Nikita$$uOregon Health and Science University$$041354
000010086 7201_ $$aChu, Cong-Qiu$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000010086 7201_ $$aSkalsky, Rebecca$$uOregon Health and Science University$$041354$$7Personal$$ePI
000010086 8564_ $$96582d365-2d50-4689-abd5-07557b76e7e1$$s2779919$$uhttps://digitalcollections.ohsu.edu/record/10086/files/Ivanov.Nikita.2023.pdf
000010086 905__ $$a/rest/prod/t7/22/h9/60/t722h960p
000010086 909CO $$ooai:digitalcollections.ohsu.edu:10086$$pstudent-work
000010086 980__ $$aScholarly Project Capstones