TY  - GEN
AB  - The neuronal M2 muscarinic receptor is a G protein-coupled receptor expressed in parasympathetic nerves that provides negative feedback for acetylcholine release. Dysfunction of neuronal M2 receptors is a mechanism for airway hyperreactivity in a variety of animal models of asthma. However, the poor specificity of available anti-M2 receptor antibodies makes quantifying M2 muscarinic receptors by immunostaining difficult, leaving unclear whether the diminished function of neuronal M2 muscarinic receptors is due to decreased protein expression. The aim of this project is to develop a novel method for measuring neuronal M2 expression in an animal model of asthma.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Hailemariam, Tseganesh
AU  - Maung, Jessica
AU  - Nie, Zhenying
DA  - 2023
DO  - 10.6083/c534fp70n
DO  - DOI
ID  - 10109
KW  - Mice
KW  - Asthma
KW  - muscarinic m2 receptor
KW  - airway hyperresponsiveness
L1  - https://digitalcollections.ohsu.edu/record/10109/files/ResearchWeek.2023.Hailemariam.Tseganesh.pdf
L2  - https://digitalcollections.ohsu.edu/record/10109/files/ResearchWeek.2023.Hailemariam.Tseganesh.pdf
L4  - https://digitalcollections.ohsu.edu/record/10109/files/ResearchWeek.2023.Hailemariam.Tseganesh.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/10109/files/ResearchWeek.2023.Hailemariam.Tseganesh.pdf
N2  - The neuronal M2 muscarinic receptor is a G protein-coupled receptor expressed in parasympathetic nerves that provides negative feedback for acetylcholine release. Dysfunction of neuronal M2 receptors is a mechanism for airway hyperreactivity in a variety of animal models of asthma. However, the poor specificity of available anti-M2 receptor antibodies makes quantifying M2 muscarinic receptors by immunostaining difficult, leaving unclear whether the diminished function of neuronal M2 muscarinic receptors is due to decreased protein expression. The aim of this project is to develop a novel method for measuring neuronal M2 expression in an animal model of asthma.
PB  - Oregon Health and Science University
PY  - 2023
T1  - Novel method to measure neuronal M2 muscarinic receptor expression
TI  - Novel method to measure neuronal M2 muscarinic receptor expression
UR  - https://digitalcollections.ohsu.edu/record/10109/files/ResearchWeek.2023.Hailemariam.Tseganesh.pdf
Y1  - 2023
ER  -