000010109 001__ 10109
000010109 005__ 20240301094517.0
000010109 0247_ $$2DOI$$a10.6083/c534fp70n
000010109 037__ $$aIR
000010109 041__ $$aeng
000010109 245__ $$aNovel method to measure neuronal M2 muscarinic receptor expression
000010109 260__ $$bOregon Health and Science University
000010109 269__ $$a2023
000010109 336__ $$aAbstract
000010109 520__ $$aThe neuronal M2 muscarinic receptor is a G protein-coupled receptor expressed in parasympathetic nerves that provides negative feedback for acetylcholine release. Dysfunction of neuronal M2 receptors is a mechanism for airway hyperreactivity in a variety of animal models of asthma. However, the poor specificity of available anti-M2 receptor antibodies makes quantifying M2 muscarinic receptors by immunostaining difficult, leaving unclear whether the diminished function of neuronal M2 muscarinic receptors is due to decreased protein expression. The aim of this project is to develop a novel method for measuring neuronal M2 expression in an animal model of asthma.
000010109 540__ $$fCC BY
000010109 542__ $$fIn copyright - joint owners
000010109 650__ $$aMice$$036842
000010109 650__ $$aAsthma$$015168
000010109 6531_ $$amuscarinic m2 receptor
000010109 6531_ $$aairway hyperresponsiveness
000010109 7001_ $$aHailemariam, Tseganesh$$uOregon Health and Science University$$041354
000010109 7001_ $$aMaung, Jessica$$uOregon Health and Science University$$041354
000010109 7001_ $$aNie, Zhenying$$uOregon Health and Science University$$041354
000010109 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000010109 8564_ $$9842b21f1-bd7a-4007-86f0-4016a1bc129f$$s198781$$uhttps://digitalcollections.ohsu.edu/record/10109/files/ResearchWeek.2023.Hailemariam.Tseganesh.pdf
000010109 905__ $$a/rest/prod/c5/34/fp/70/c534fp70n
000010109 980__ $$aResearch Week