000010111 001__ 10111 000010111 005__ 20240124114337.0 000010111 0247_ $$2DOI$$a10.6083/3197xn00n 000010111 037__ $$aETD 000010111 245__ $$aMicrofluidic on-chip analysis of dielectrophoresis isolated cancer biomarkers from liquid biopsy 000010111 260__ $$bOregon Health and Science University 000010111 269__ $$a2023 000010111 336__ $$aThesis 000010111 502__ $$bPh.D. 000010111 520__ $$aThis thesis focuses on the development of early cancer detection methods for oral and pancreatic cancer through the design of a novel system for liquid biopsy-based biomarker recovery and subsequent analysis from undiluted body fluids. This work addresses the critical clinical need to improve the signal-to-noise ratio of cancer biomarkers in early stages and improve test accessibility for the general population. 000010111 650__ $$aPoint-of-Care Systems$$031352 000010111 650__ $$aSynthetic Biology$$039275 000010111 6531_ $$acfdna 000010111 6531_ $$aoral cancer 000010111 691__ $$aSchool of Medicine$$041369 000010111 692__ $$aDepartment of Biomedical Engineering$$041397 000010111 7001_ $$aHamilton, Sean R. 000010111 8564_ $$9c8e08c8d-a832-4b3e-a9d2-c6225839913f$$s11706713$$uhttps://digitalcollections.ohsu.edu/record/10111/files/Hamilton.Sean.2023.pdf 000010111 905__ $$a/rest/prod/31/97/xn/00/3197xn00n 000010111 909CO $$ooai:digitalcollections.ohsu.edu:10111$$pstudent-work 000010111 980__ $$aTheses and Dissertations