@article{ETD, recid = {10134}, author = {Engeln, Kimberley A.}, title = {Behavioral and synaptic plasticity accompanying incubation of oxycodone craving}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2023}, number = {ETD}, abstract = {Opioid use disorder is a chronic relapsing disease. Relapse is precipitated by cravings for the euphoric, rewarding effects of opioids as well as a desire to alleviate physical and emotional pain. Cravings can be triggered by external cues and negative emotional states associated with previous drug use. Identifying the neuronal mechanisms that underlie cue-induced cravings is critical for developing treatments that can prevent relapse. In this dissertation, I describe pathological behavioral and neuronal plasticity that emerges during abstinence from chronic prescription opioid use and contributes to heightened responding for opioid-associated cues.}, url = {http://digitalcollections.ohsu.edu/record/10134}, doi = {https://doi.org/10.6083/k35695096}, }