@article{ETD, school = {Ph.D.}, author = {Engeln, Kimberley A.}, url = {http://digitalcollections.ohsu.edu/record/10134}, title = {Behavioral and synaptic plasticity accompanying incubation of oxycodone craving}, publisher = {Oregon Health and Science University}, abstract = {Opioid use disorder is a chronic relapsing disease. Relapse is precipitated by cravings for the euphoric, rewarding effects of opioids as well as a desire to alleviate physical and emotional pain. Cravings can be triggered by external cues and negative emotional states associated with previous drug use. Identifying the neuronal mechanisms that underlie cue-induced cravings is critical for developing treatments that can prevent relapse. In this dissertation, I describe pathological behavioral and neuronal plasticity that emerges during abstinence from chronic prescription opioid use and contributes to heightened responding for opioid-associated cues.}, number = {ETD}, doi = {https://doi.org/10.6083/k35695096}, recid = {10134}, address = {2023}, }