TY  - GEN
N2  - Opioid use disorder is a chronic relapsing disease. Relapse is precipitated by cravings for the euphoric, rewarding effects of opioids as well as a desire to alleviate physical and emotional pain. Cravings can be triggered by external cues and negative emotional states associated with previous drug use. Identifying the neuronal mechanisms that underlie cue-induced cravings is critical for developing treatments that can prevent relapse. In this dissertation, I describe pathological behavioral and neuronal plasticity that emerges during abstinence from chronic prescription opioid use and contributes to heightened responding for opioid-associated cues.
DO  - 10.6083/k35695096
DO  - DOI
AB  - Opioid use disorder is a chronic relapsing disease. Relapse is precipitated by cravings for the euphoric, rewarding effects of opioids as well as a desire to alleviate physical and emotional pain. Cravings can be triggered by external cues and negative emotional states associated with previous drug use. Identifying the neuronal mechanisms that underlie cue-induced cravings is critical for developing treatments that can prevent relapse. In this dissertation, I describe pathological behavioral and neuronal plasticity that emerges during abstinence from chronic prescription opioid use and contributes to heightened responding for opioid-associated cues.
T1  - Behavioral and synaptic plasticity accompanying incubation of oxycodone craving
DA  - 2023
AU  - Engeln, Kimberley A.
L1  - https://digitalcollections.ohsu.edu/record/10134/files/Engeln.Kim.2023.pdf
PB  - Oregon Health and Science University
PY  - 2023
ID  - 10134
L4  - https://digitalcollections.ohsu.edu/record/10134/files/Engeln.Kim.2023.pdf
KW  - Opioid-Related Disorders
KW  - Nucleus Accumbens
KW  - Glutamates
KW  - Neuronal Plasticity
KW  - Self Administration
KW  - opioids
TI  - Behavioral and synaptic plasticity accompanying incubation of oxycodone craving
Y1  - 2023
L2  - https://digitalcollections.ohsu.edu/record/10134/files/Engeln.Kim.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/10134/files/Engeln.Kim.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/10134/files/Engeln.Kim.2023.pdf
ER  -