000010134 001__ 10134
000010134 005__ 20240124114338.0
000010134 0247_ $$2DOI$$a10.6083/k35695096
000010134 037__ $$aETD
000010134 245__ $$aBehavioral and synaptic plasticity accompanying incubation of oxycodone craving
000010134 260__ $$bOregon Health and Science University
000010134 269__ $$a2023
000010134 336__ $$aDissertation
000010134 502__ $$bPh.D.
000010134 520__ $$aOpioid use disorder is a chronic relapsing disease. Relapse is precipitated by cravings for the euphoric, rewarding effects of opioids as well as a desire to alleviate physical and emotional pain. Cravings can be triggered by external cues and negative emotional states associated with previous drug use. Identifying the neuronal mechanisms that underlie cue-induced cravings is critical for developing treatments that can prevent relapse. In this dissertation, I describe pathological behavioral and neuronal plasticity that emerges during abstinence from chronic prescription opioid use and contributes to heightened responding for opioid-associated cues.
000010134 542__ $$fIn copyright - single owner
000010134 650__ $$aOpioid-Related Disorders$$022689
000010134 650__ $$aNucleus Accumbens$$023067
000010134 650__ $$aGlutamates$$019605
000010134 650__ $$aNeuronal Plasticity$$022857
000010134 650__ $$aSelf Administration$$025838
000010134 6531_ $$aopioids
000010134 691__ $$aSchool of Medicine$$041369
000010134 692__ $$aVollum Institute$$041509
000010134 7001_ $$aEngeln, Kimberley A.
000010134 8564_ $$925789ff8-775f-4b27-a665-c81de3f2bbc8$$s2317111$$uhttps://digitalcollections.ohsu.edu/record/10134/files/Engeln.Kim.2023.pdf
000010134 905__ $$a/rest/prod/k3/56/95/09/k35695096
000010134 909CO $$ooai:digitalcollections.ohsu.edu:10134$$pstudent-work
000010134 980__ $$aTheses and Dissertations