TY  - THES
N2  - Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in adults. Owing to a high level of disease heterogeneity and common recurrence, 5-year survival is below 10% with a near 100% mortality rate. Early and accurate diagnosis of GBM is vital for disease identification, treatment planning, and therapy response assessment. Such diag-noses are often made using dynamic contrast-enhanced magnetic resonance imaging (MRI) and positron emission tomography (PET). These imaging techniques not only outline the anatomical structure of the tumor, but also indicate physiological characteristics including blood flow and oxygen content within its microenvironment. These features are clinically sig-nificant, as disease prognosis and treatment efficacy are modulated by hypervascularization and reduced oxygen content (hypoxia).
DO  - 10.6083/xg94hq191
DO  - DOI
AB  - Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in adults. Owing to a high level of disease heterogeneity and common recurrence, 5-year survival is below 10% with a near 100% mortality rate. Early and accurate diagnosis of GBM is vital for disease identification, treatment planning, and therapy response assessment. Such diag-noses are often made using dynamic contrast-enhanced magnetic resonance imaging (MRI) and positron emission tomography (PET). These imaging techniques not only outline the anatomical structure of the tumor, but also indicate physiological characteristics including blood flow and oxygen content within its microenvironment. These features are clinically sig-nificant, as disease prognosis and treatment efficacy are modulated by hypervascularization and reduced oxygen content (hypoxia).
T1  - Evaluation of hypoxia and perfusion in glioblastoma multiforme using pseudo-dynamic PET imaging with [18F]-fluoromisonidazole
DA  - 2023
AU  - Wishart, Joseph
L1  - https://digitalcollections.ohsu.edu/record/10135/files/Wishart.Joseph.2023.pdf
PB  - Oregon Health and Science University
PY  - 2023
ID  - 10135
L4  - https://digitalcollections.ohsu.edu/record/10135/files/Wishart.Joseph.2023.pdf
KW  - Perfusion
KW  - Glioblastoma
KW  - Magnetic Resonance Imaging
KW  - Hypoxia
KW  - pet imaging
KW  - fluoromisonidazole
TI  - Evaluation of hypoxia and perfusion in glioblastoma multiforme using pseudo-dynamic PET imaging with [18F]-fluoromisonidazole
Y1  - 2023
L2  - https://digitalcollections.ohsu.edu/record/10135/files/Wishart.Joseph.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/10135/files/Wishart.Joseph.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/10135/files/Wishart.Joseph.2023.pdf
ER  -