000010135 001__ 10135
000010135 005__ 20240124114338.0
000010135 0247_ $$2DOI$$a10.6083/xg94hq191
000010135 037__ $$aETD
000010135 245__ $$aEvaluation of hypoxia and perfusion in glioblastoma multiforme using pseudo-dynamic PET imaging with [18F]-fluoromisonidazole
000010135 260__ $$bOregon Health and Science University
000010135 269__ $$a2023
000010135 336__ $$aThesis
000010135 502__ $$bM.S.
000010135 520__ $$aGlioblastoma multiforme (GBM) is the most common and aggressive brain tumor in adults. Owing to a high level of disease heterogeneity and common recurrence, 5-year survival is below 10% with a near 100% mortality rate. Early and accurate diagnosis of GBM is vital for disease identification, treatment planning, and therapy response assessment. Such diag-noses are often made using dynamic contrast-enhanced magnetic resonance imaging (MRI) and positron emission tomography (PET). These imaging techniques not only outline the anatomical structure of the tumor, but also indicate physiological characteristics including blood flow and oxygen content within its microenvironment. These features are clinically sig-nificant, as disease prognosis and treatment efficacy are modulated by hypervascularization and reduced oxygen content (hypoxia).
000010135 650__ $$aPerfusion$$023790
000010135 650__ $$aGlioblastoma$$019547
000010135 650__ $$aMagnetic Resonance Imaging$$021747
000010135 650__ $$aHypoxia$$014810
000010135 6531_ $$apet imaging
000010135 6531_ $$afluoromisonidazole
000010135 691__ $$aSchool of Medicine$$041369
000010135 7001_ $$aWishart, Joseph
000010135 8564_ $$9997a92b2-0853-443c-b0f1-a5083e8d59c2$$s18212954$$uhttps://digitalcollections.ohsu.edu/record/10135/files/Wishart.Joseph.2023.pdf
000010135 905__ $$a/rest/prod/xg/94/hq/19/xg94hq191
000010135 909CO $$ooai:digitalcollections.ohsu.edu:10135$$pstudent-work
000010135 980__ $$aTheses and Dissertations