@article{ETD, school = {Ph.D.}, author = {Farley, Scotland E.}, url = {http://digitalcollections.ohsu.edu/record/10138}, title = {Disentangling the web: the synthesis of functional lipid probes to study metabolic rewiring in RNA virus infection}, publisher = {Oregon Health and Science University}, abstract = {There is a surprisingly large gap between the urgency of understanding the basic biology of pathogenic viruses and the tools and strategies that have been brought to bear. Unraveling the host dependency factors that support viral pathogenesis, and identifying viral factors that interact with the host to facilitate their life cycles, is the basis of our ability to develop antiviral strategies. The fundamental hypothesis guiding my dissertation work has been that (+)-sense viruses of the flavivirus and coronavirus genre manipulate host lipid metabolism, and further, that this lipid remodeling is a critical part of the viral life cycle. By necessity, this has been an extremely interdisciplinary project, ranging from chemical synthesis of relevant lipid probes, through the analytic chemistry techniques of lipidomics and proteomics, ultimately applied to and in conversation with virology.}, number = {ETD}, doi = {https://doi.org/10.6083/3484zh75r}, recid = {10138}, address = {2023}, }