TY  - GEN
N2  - There is a surprisingly large gap between the urgency of understanding the basic biology of pathogenic viruses and the tools and strategies that have been brought to bear. Unraveling the host dependency factors that support viral pathogenesis, and identifying viral factors that interact with the host to facilitate their life cycles, is the basis of our ability to develop antiviral strategies. The fundamental hypothesis guiding my dissertation work has been that (+)-sense viruses of the flavivirus and coronavirus genre manipulate host lipid metabolism, and further, that this lipid remodeling is a critical part of the viral life cycle. By necessity, this has been an extremely interdisciplinary project, ranging from chemical synthesis of relevant lipid probes, through the analytic chemistry techniques of lipidomics and proteomics, ultimately applied to and in conversation with virology.
DO  - 10.6083/3484zh75r
DO  - DOI
AB  - There is a surprisingly large gap between the urgency of understanding the basic biology of pathogenic viruses and the tools and strategies that have been brought to bear. Unraveling the host dependency factors that support viral pathogenesis, and identifying viral factors that interact with the host to facilitate their life cycles, is the basis of our ability to develop antiviral strategies. The fundamental hypothesis guiding my dissertation work has been that (+)-sense viruses of the flavivirus and coronavirus genre manipulate host lipid metabolism, and further, that this lipid remodeling is a critical part of the viral life cycle. By necessity, this has been an extremely interdisciplinary project, ranging from chemical synthesis of relevant lipid probes, through the analytic chemistry techniques of lipidomics and proteomics, ultimately applied to and in conversation with virology.
T1  - Disentangling the web: the synthesis of functional lipid probes to study metabolic rewiring in RNA virus infection
DA  - 2023
AU  - Farley, Scotland E.
L1  - https://digitalcollections.ohsu.edu/record/10138/files/Farley.Scotland.2023.pdf
PB  - Oregon Health and Science University
PY  - 2023
ID  - 10138
L4  - https://digitalcollections.ohsu.edu/record/10138/files/Farley.Scotland.2023.pdf
KW  - Biology
KW  - Host-Pathogen Interactions
KW  - Lipidomics
KW  - Lipids
KW  - Biochemistry
KW  - Virology
TI  - Disentangling the web: the synthesis of functional lipid probes to study metabolic rewiring in RNA virus infection
Y1  - 2023
L2  - https://digitalcollections.ohsu.edu/record/10138/files/Farley.Scotland.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/10138/files/Farley.Scotland.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/10138/files/Farley.Scotland.2023.pdf
ER  -