000010138 001__ 10138
000010138 005__ 20231129124954.0
000010138 0247_ $$2DOI$$a10.6083/3484zh75r
000010138 037__ $$aETD
000010138 245__ $$aDisentangling the web: the synthesis of functional lipid probes to study metabolic rewiring in RNA virus infection
000010138 260__ $$bOregon Health and Science University
000010138 269__ $$a2023
000010138 336__ $$aDissertation
000010138 502__ $$bPh.D.
000010138 520__ $$aThere is a surprisingly large gap between the urgency of understanding the basic biology of pathogenic viruses and the tools and strategies that have been brought to bear. Unraveling the host dependency factors that support viral pathogenesis, and identifying viral factors that interact with the host to facilitate their life cycles, is the basis of our ability to develop antiviral strategies. The fundamental hypothesis guiding my dissertation work has been that (+)-sense viruses of the flavivirus and coronavirus genre manipulate host lipid metabolism, and further, that this lipid remodeling is a critical part of the viral life cycle. By necessity, this has been an extremely interdisciplinary project, ranging from chemical synthesis of relevant lipid probes, through the analytic chemistry techniques of lipidomics and proteomics, ultimately applied to and in conversation with virology.
000010138 542__ $$fIn copyright - single owner
000010138 650__ $$aBiology$$015571
000010138 650__ $$aHost-Pathogen Interactions$$038099
000010138 650__ $$aLipidomics$$013258
000010138 650__ $$aLipids$$021539
000010138 650__ $$aBiochemistry$$015549
000010138 650__ $$aVirology$$027843
000010138 691__ $$aSchool of Medicine$$041369
000010138 692__ $$aDepartment of Chemical Physiology and Biochemistry$$041400
000010138 7001_ $$aFarley, Scotland E.
000010138 8564_ $$97d63b243-9797-47e2-9078-db8e366a98b9$$s10610793$$uhttps://digitalcollections.ohsu.edu/record/10138/files/Farley.Scotland.2023.pdf
000010138 905__ $$a/rest/prod/34/84/zh/75/3484zh75r
000010138 909CO $$ooai:digitalcollections.ohsu.edu:10138$$pstudent-work
000010138 980__ $$aTheses and Dissertations