@article{ETD,
      recid = {10139},
      author = {Lan, Yuxin},
      title = {Exploring the feasibility of utilizing standard uptake  value and pseudo-reference region modeling for  quantification of [11C]PBR28 activity from dynamic positron  emission tomography acquisitions in a population of  methamphetamine users},
      publisher = {Oregon Health and Science University},
      school = {M.S.},
      address = {2023},
      number = {ETD},
      abstract = {Stimulant use can trigger a neuroimmune response and  render the central nervous system vulnerable by activating  microglia and leading to cell migration, pro-inflammatory  factor production, and reactive oxygen and nitrogen  secretion. Activated microglia leads to the expression of  TSPO, a 18kDa translocator protein formerly denoted as the  peripheral benzodiazepine receptor (PBR), which can be  utilized as a target to index neuroinflammation. The  objective of this thesis was to explore the feasibility of  using standard uptake value (SUV) and pseudo-reference  region modeling for PET quantification. The regions of  interest (ROIs) were middle frontal gyrus, ventral  striatum, and amygdala. SUV data was acquired directly from  PET sequences. Non-displaceable binding potential (BPND)  data was derived using the simplified reference tissue  model (SRTM), with cerebellar gray matter as the  pseudo-reference region.},
      url = {http://digitalcollections.ohsu.edu/record/10139},
      doi = {https://doi.org/10.6083/6h440t27k},
}