TY  - THES
AB  - Stimulant use can trigger a neuroimmune response and render the central nervous system vulnerable by activating microglia and leading to cell migration, pro-inflammatory factor production, and reactive oxygen and nitrogen secretion. Activated microglia leads to the expression of TSPO, a 18kDa translocator protein formerly denoted as the peripheral benzodiazepine receptor (PBR), which can be utilized as a target to index neuroinflammation. The objective of this thesis was to explore the feasibility of using standard uptake value (SUV) and pseudo-reference region modeling for PET quantification. The regions of interest (ROIs) were middle frontal gyrus, ventral striatum, and amygdala. SUV data was acquired directly from PET sequences. Non-displaceable binding potential (BPND) data was derived using the simplified reference tissue model (SRTM), with cerebellar gray matter as the pseudo-reference region.
AU  - Lan, Yuxin
DA  - 2023
DO  - 10.6083/6h440t27k
DO  - DOI
ID  - 10139
KW  - Substance-Related Disorders
KW  - Neuroinflammatory Diseases
KW  - Pharmacogenomic Variants
KW  - Methamphetamine
KW  - Positron-Emission Tomography
KW  - experimental models
L1  - https://digitalcollections.ohsu.edu/record/10139/files/Lan.Yuxin.2023.pdf
L2  - https://digitalcollections.ohsu.edu/record/10139/files/Lan.Yuxin.2023.pdf
L4  - https://digitalcollections.ohsu.edu/record/10139/files/Lan.Yuxin.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/10139/files/Lan.Yuxin.2023.pdf
N2  - Stimulant use can trigger a neuroimmune response and render the central nervous system vulnerable by activating microglia and leading to cell migration, pro-inflammatory factor production, and reactive oxygen and nitrogen secretion. Activated microglia leads to the expression of TSPO, a 18kDa translocator protein formerly denoted as the peripheral benzodiazepine receptor (PBR), which can be utilized as a target to index neuroinflammation. The objective of this thesis was to explore the feasibility of using standard uptake value (SUV) and pseudo-reference region modeling for PET quantification. The regions of interest (ROIs) were middle frontal gyrus, ventral striatum, and amygdala. SUV data was acquired directly from PET sequences. Non-displaceable binding potential (BPND) data was derived using the simplified reference tissue model (SRTM), with cerebellar gray matter as the pseudo-reference region.
PB  - Oregon Health and Science University
PY  - 2023
T1  - Exploring the feasibility of utilizing standard uptake value and pseudo-reference region modeling for quantification of [11C]PBR28 activity from dynamic positron emission tomography acquisitions in a population of methamphetamine users
TI  - Exploring the feasibility of utilizing standard uptake value and pseudo-reference region modeling for quantification of [11C]PBR28 activity from dynamic positron emission tomography acquisitions in a population of methamphetamine users
UR  - https://digitalcollections.ohsu.edu/record/10139/files/Lan.Yuxin.2023.pdf
Y1  - 2023
ER  -