000010139 001__ 10139
000010139 005__ 20240124114338.0
000010139 0247_ $$2DOI$$a10.6083/6h440t27k
000010139 037__ $$aETD
000010139 245__ $$aExploring the feasibility of utilizing standard uptake value and pseudo-reference region modeling for quantification of [11C]PBR28 activity from dynamic positron emission tomography acquisitions in a population of methamphetamine users
000010139 260__ $$bOregon Health and Science University
000010139 269__ $$a2023
000010139 336__ $$aThesis
000010139 502__ $$bM.S.
000010139 520__ $$aStimulant use can trigger a neuroimmune response and render the central nervous system vulnerable by activating microglia and leading to cell migration, pro-inflammatory factor production, and reactive oxygen and nitrogen secretion. Activated microglia leads to the expression of TSPO, a 18kDa translocator protein formerly denoted as the peripheral benzodiazepine receptor (PBR), which can be utilized as a target to index neuroinflammation. The objective of this thesis was to explore the feasibility of using standard uptake value (SUV) and pseudo-reference region modeling for PET quantification. The regions of interest (ROIs) were middle frontal gyrus, ventral striatum, and amygdala. SUV data was acquired directly from PET sequences. Non-displaceable binding potential (BPND) data was derived using the simplified reference tissue model (SRTM), with cerebellar gray matter as the pseudo-reference region.
000010139 650__ $$aSubstance-Related Disorders$$032029
000010139 650__ $$aNeuroinflammatory Diseases$$013756
000010139 650__ $$aPharmacogenomic Variants$$011717
000010139 650__ $$aMethamphetamine$$022135
000010139 650__ $$aPositron-Emission Tomography$$036178
000010139 6531_ $$aexperimental models
000010139 691__ $$aSchool of Medicine$$041369
000010139 7001_ $$aLan, Yuxin
000010139 8564_ $$960618690-3e7b-4fab-b9f6-87b96430ac57$$s3228056$$uhttps://digitalcollections.ohsu.edu/record/10139/files/Lan.Yuxin.2023.pdf
000010139 905__ $$a/rest/prod/6h/44/0t/27/6h440t27k
000010139 909CO $$ooai:digitalcollections.ohsu.edu:10139$$pstudent-work
000010139 980__ $$aTheses and Dissertations