000000126 001__ 126
000000126 005__ 20260420134417.0
000000126 0247_ $$2DOI$$a10.6083/M4Q23X5K
000000126 037__ $$aETD
000000126 245__ $$aCompact fiber-optic diffuse reflection probes for medical diagnostics
000000126 260__ $$bOregon Health and Science University
000000126 269__ $$a2007
000000126 336__ $$aDissertation
000000126 502__ $$bPh.D.
000000126 502__ $$gComputer Science & Electrical Engineering (sunsetting)
000000126 520__ $$aFiber-optic probes offer a minimally invasive approach for tissue biopsy by measuring optical absorption and scattering properties that reflect tissue composition and structure. This work investigates fiber-optic reflectometry devices designed to sample very small tissue volumes using backscattered light. Two complementary studies establish tools for probe evaluation: the fabrication of stable, optically characterized tissue phantoms, and a combined inverse adding-doubling/Monte Carlo model for accurately determining optical properties. A novel sized-fiber reflectometry probe is developed and validated experimentally and through simulation, demonstrating predictable sampling depth, high scattering sensitivity, and reduced measurement variability using beveled fibers. A clinical study further demonstrates the probe’s utility by accurately distinguishing oral melanotic lesions from amalgam tattoos based on spectral reflectance, highlighting the potential of fiber-optic techniques for optical diagnosis.
000000126 540__ $$fCC BY
000000126 542__ $$fIn copyright - single owner
000000126 650__ $$aDiagnosis$$017684
000000126 650__ $$aEquipment and Supplies$$018566
000000126 650__ $$aDiagnostic Equipment$$031824
000000126 650__ $$aFiber Optic Technology$$019009
000000126 6531_ $$amonte carlo modeling
000000126 6531_ $$adiffuse reflectance
000000126 6531_ $$afiber-optics
000000126 6531_ $$aspectroscopy
000000126 6531_ $$afiber optics
000000126 691__ $$aOGI School of Science and Engineering$$041365
000000126 692__ $$aDepartment of Biomedical Engineering$$041397
000000126 7001_ $$aMoffitt, Theodore$$uOregon Health and Science University$$041354
000000126 7201_ $$aPrahl, Scott$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000126 8564_ $$99f5872f2-c8c2-4335-9f2e-7c5612bf5991$$s18022830$$uhttps://digitalcollections.ohsu.edu/record/126/files/126_etd.pdf$$ePublic$$26c4d6e6df7eb80ce7516b8c44cc9d217$$31
000000126 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000126 905__ $$a/rest/prod/x0/59/c7/32/x059c7329
000000126 909CO $$ooai:digitalcollections.ohsu.edu:126$$pstudent-work
000000126 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000126 980__ $$aTheses and Dissertations