000000188 001__ 188
000000188 005__ 20251007004805.0
000000188 0247_ $$2DOI$$a10.6083/M4PR7SXW
000000188 037__ $$aETD
000000188 245__ $$aGene mapping in complex traits  gene expression profiling and copy number variability in gene mapping of age-related cognitive decline
000000188 269__ $$a2007
000000188 336__ $$aDissertation
000000188 502__ $$bPh.D.
000000188 520__ $$aHistorically, most advances in gene mapping have occurred through the use of linkage analysis in family studies of Mendelian diseases. Translating these successes into finding genes involved in complex traits has been problematic.  The main challenges are that complex traits are comprised of multiple genes of varying effect sizes and that epistatic interactions among multiple genes and the environment contribute to the phenotype. The objective of this research is to investigate alternative strategies for mapping complex traits.
000000188 540__ $$fCC BY
000000188 542__ $$fIn copyright - single owner
000000188 650__ $$aEpidemiologic Research Design$$028334
000000188 650__ $$aMicroarray Analysis$$035790
000000188 650__ $$aGene Dosage$$030962
000000188 650__ $$aChromosome Mapping$$016681
000000188 650__ $$aAlzheimer Disease$$014513
000000188 650__ $$aGene Expression$$028717
000000188 650__ $$aPolymorphism, Single Nucleotide$$032570
000000188 691__ $$aSchool of Medicine$$041369
000000188 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000000188 7001_ $$aWilmot, Beth$$uOregon Health and Science University$$041354
000000188 7201_ $$aKramer, Patricia$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000188 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000188 8564_ $$90cb8ecb0-c86f-4ca7-beef-6f5ec6113e55$$s3776688$$uhttps://digitalcollections.ohsu.edu/record/188/files/188_etd.pdf$$ePublic$$2d41d42eb96482990a1d0bc289755e071$$31
000000188 905__ $$a/rest/prod/z3/16/q1/56/z316q156s
000000188 909CO $$ooai:digitalcollections.ohsu.edu:188$$pstudent-work
000000188 980__ $$aTheses and Dissertations