000002135 001__ 2135
000002135 005__ 20260513063915.0
000002135 0247_ $$2DOI$$a10.6083/M4ZG6QH1
000002135 037__ $$aETD
000002135 245__ $$aHoxa13 is essential for placental vascular patterning and endothelial cell integrity
000002135 260__ $$bOregon Health and Science University
000002135 269__ $$a2006
000002135 336__ $$aDissertation
000002135 502__ $$bPh.D.
000002135 502__ $$gMolecular & Medical Genetics (sunsetting)
000002135 520__ $$aSuccessful embryonic development in eutherian mammals depends on proper placental vascularization. Hoxa13, a HOX transcription factor, is strongly expressed in developing umbilical arteries and placental endothelial cells. Using histology, gene expression analyses, and functional assays, this study demonstrates that loss of Hoxa13 disrupts placental vascular patterning, resulting in a reduced and poorly branched labyrinthine vasculature. Microarray and molecular analyses identified Tie2 and Foxf1 as direct transcriptional targets of HOXA13. These findings establish Hoxa13 as a key regulator of placental vascular development essential for embryonic survival.
000002135 540__ $$fCC BY
000002135 542__ $$fIn copyright - single owner
000002135 650__ $$aPlacenta$$024210
000002135 650__ $$aHomeodomain Proteins$$030771
000002135 650__ $$aPlacental Circulation$$032853
000002135 650__ $$aEmbryonic and Fetal Development$$018987
000002135 650__ $$aEndothelial Cells$$035222
000002135 650__ $$aEutheria$$012167
000002135 650__ $$aPregnancy$$024523
000002135 650__ $$aEmbryonic Development$$035917
000002135 691__ $$aSchool of Medicine$$041369
000002135 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000002135 7001_ $$aEgelston Shaut, Carley$$uOregon Health and Science University$$041354
000002135 7201_ $$aStadler, H. Scott$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000002135 8564_ $$9fcac079f-6d53-48de-bdac-339880d65032$$s7946381$$uhttps://digitalcollections.ohsu.edu/record/2135/files/2864_etd.pdf$$ePublic$$2e92f4966bd2e2bffe9bef2e6c2686197$$31
000002135 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002135 905__ $$a/rest/prod/k9/30/bx/09/k930bx099
000002135 909CO $$ooai:digitalcollections.ohsu.edu:2135$$pstudent-work
000002135 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002135 980__ $$aTheses and Dissertations