@article{ETD,
      recid = {2155},
      author = {Dalgin, Gokhan},
      title = {GATA-2 functions downstream of BMPs and CaM KIV in  ectodermal cells during primitive hematopoiesis},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2006},
      number = {ETD},
      abstract = {Primitive hematopoiesis in Xenopus requires signals from  both mesoderm and neighboring ectoderm, yet the molecular  regulators of these ectodermal signals are not fully  defined. This study demonstrates that the transcription  factor GATA-2 is required in the ectoderm for normal blood  development. Loss of GATA-2 function produces hematopoietic  defects similar to those caused by disruption of BMP  signaling or CaMKIV activity. The data support a linear  pathway in which BMPs induce GATA-2 transcription, while  CaMKIV negatively regulates GATA-2 activity  post-translationally, revealing a coordinated mechanism  controlling early blood lineage specification.},
      url = {http://digitalcollections.ohsu.edu/record/2155},
      doi = {https://doi.org/10.6083/M4CJ8BQB},
}