TY  - GEN
AB  - Primitive hematopoiesis in Xenopus requires signals from both mesoderm and neighboring ectoderm, yet the molecular regulators of these ectodermal signals are not fully defined. This study demonstrates that the transcription factor GATA-2 is required in the ectoderm for normal blood development. Loss of GATA-2 function produces hematopoietic defects similar to those caused by disruption of BMP signaling or CaMKIV activity. The data support a linear pathway in which BMPs induce GATA-2 transcription, while CaMKIV negatively regulates GATA-2 activity post-translationally, revealing a coordinated mechanism controlling early blood lineage specification.
AD  - Oregon Health and Science University
AU  - Dalgin, Gokhan
DA  - 2006
DO  - 10.6083/M4CJ8BQB
DO  - DOI
ED  - Christian, Jan
ED  - Advisor
ID  - 2155
KW  - GATA2 Transcription Factor
KW  - Xenopus laevis
KW  - Bone Morphogenetic Proteins
KW  - Hematopoiesis
KW  - Calcium-Binding Proteins
KW  - Calcium-Calmodulin-Dependent Protein Kinases
KW  - Acetylation
L1  - https://digitalcollections.ohsu.edu/record/2155/files/2884_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2155/files/2884_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2155/files/2884_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2155/files/2884_etd.pdf
N2  - Primitive hematopoiesis in Xenopus requires signals from both mesoderm and neighboring ectoderm, yet the molecular regulators of these ectodermal signals are not fully defined. This study demonstrates that the transcription factor GATA-2 is required in the ectoderm for normal blood development. Loss of GATA-2 function produces hematopoietic defects similar to those caused by disruption of BMP signaling or CaMKIV activity. The data support a linear pathway in which BMPs induce GATA-2 transcription, while CaMKIV negatively regulates GATA-2 activity post-translationally, revealing a coordinated mechanism controlling early blood lineage specification.
PB  - Oregon Health and Science University
PY  - 2006
T1  - GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis
TI  - GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis
UR  - https://digitalcollections.ohsu.edu/record/2155/files/2884_etd.pdf
Y1  - 2006
ER  -