@article{ETD,
      recid = {2157},
      author = {Metcalf Hoffman, Katherine},
      title = {DNA recognition by prokaryotic transcriptional regulators},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2006},
      number = {ETD},
      abstract = {Precise regulation of protein production is essential for  cellular efficiency and homeostasis, particularly for  enzymes and transport systems whose overexpression can be  detrimental. This thesis investigates transcriptional  regulation, focusing on DNA–protein interactions as a  primary control mechanism of gene expression. Using the  bacterial regulators PurR from Escherichia coli and MtrR  from Neisseria gonorrhoeae as model systems, a combination  of biochemical, biophysical, and structural approaches was  employed to examine their DNA binding mechanisms. Findings  provide insight into direct and indirect DNA recognition  and the functional properties of regulatory domains,  enhancing understanding of transcriptional control in  bacterial systems.},
      url = {http://digitalcollections.ohsu.edu/record/2157},
      doi = {https://doi.org/10.6083/M4445JRT},
}