TY  - GEN
AB  - Sensory hair cells adapt to sustained mechanical stimulation through Ca²⁺-dependent closure of transduction channels via fast and slow mechanisms. Using genetically sensitized mouse models, this study examined the roles of myosin-1c (Myo1c) and myosin-7a (Myo7a) in hair-cell adaptation. Pharmacological inhibition of Myo1c blocked both fast and slow adaptation in vestibular hair cells, indicating a mechanical role for Myo1c in both processes. Studies of Myo7a suggest it is essential for proper transduction and bundle organization, highlighting distinct myosin contributions to hair-cell adaptation and auditory function.
AD  - Oregon Health and Science University
AU  - Scarborough, John
DA  - 2006
DO  - 10.6083/M4VM49J6
DO  - DOI
ID  - 2159
KW  - Myosins
KW  - Cochlea
KW  - Hair Cells, Vestibular
KW  - Mice
KW  - Hair Cells, Auditory
KW  - Mechanotransduction, Cellular
L1  - https://digitalcollections.ohsu.edu/record/2159/files/2888_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2159/files/2888_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2159/files/2888_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2159/files/2888_etd.pdf
N2  - Sensory hair cells adapt to sustained mechanical stimulation through Ca²⁺-dependent closure of transduction channels via fast and slow mechanisms. Using genetically sensitized mouse models, this study examined the roles of myosin-1c (Myo1c) and myosin-7a (Myo7a) in hair-cell adaptation. Pharmacological inhibition of Myo1c blocked both fast and slow adaptation in vestibular hair cells, indicating a mechanical role for Myo1c in both processes. Studies of Myo7a suggest it is essential for proper transduction and bundle organization, highlighting distinct myosin contributions to hair-cell adaptation and auditory function.
PB  - Oregon Health and Science University
PY  - 2006
T1  - Hair-cell adaptation motors: a chemical-genetic approach
TI  - Hair-cell adaptation motors: a chemical-genetic approach
UR  - https://digitalcollections.ohsu.edu/record/2159/files/2888_etd.pdf
Y1  - 2006
ER  -