000002159 001__ 2159
000002159 005__ 20260513065554.0
000002159 0247_ $$2DOI$$a10.6083/M4VM49J6
000002159 037__ $$aETD
000002159 245__ $$aHair-cell adaptation motors: a chemical-genetic approach
000002159 260__ $$bOregon Health and Science University
000002159 269__ $$a2006
000002159 336__ $$aDissertation
000002159 502__ $$bPh.D.
000002159 520__ $$aSensory hair cells adapt to sustained mechanical stimulation through Ca²⁺-dependent closure of transduction channels via fast and slow mechanisms. Using genetically sensitized mouse models, this study examined the roles of myosin-1c (Myo1c) and myosin-7a (Myo7a) in hair-cell adaptation. Pharmacological inhibition of Myo1c blocked both fast and slow adaptation in vestibular hair cells, indicating a mechanical role for Myo1c in both processes. Studies of Myo7a suggest it is essential for proper transduction and bundle organization, highlighting distinct myosin contributions to hair-cell adaptation and auditory function.
000002159 540__ $$fCC BY
000002159 542__ $$fIn copyright - single owner
000002159 650__ $$aMyosins$$022616
000002159 650__ $$aCochlea$$016848
000002159 650__ $$aHair Cells, Vestibular$$030477
000002159 650__ $$aMice$$036842
000002159 650__ $$aHair Cells, Auditory$$019810
000002159 650__ $$aMechanotransduction, Cellular$$035047
000002159 691__ $$aSchool of Medicine$$041369
000002159 692__ $$aVollum Institute$$041509
000002159 692__ $$aOregon Hearing Research Center$$041495
000002159 7001_ $$aScarborough, John$$uOregon Health and Science University$$041354
000002159 8564_ $$9e233ea40-f769-414f-81f2-8c514a31e3e0$$s5908124$$uhttps://digitalcollections.ohsu.edu/record/2159/files/2888_etd.pdf$$ePublic$$247135ee17efd214d4d44a1237f156ee1$$31
000002159 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002159 905__ $$a/rest/prod/0g/35/4f/37/0g354f370
000002159 909CO $$ooai:digitalcollections.ohsu.edu:2159$$pstudent-work
000002159 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002159 980__ $$aTheses and Dissertations