000002164 001__ 2164
000002164 005__ 20260428140228.0
000002164 0247_ $$2DOI$$a10.6083/M46W98BV
000002164 037__ $$aETD
000002164 245__ $$aSex differences in the effect of finasteride on acute ethanol withdrawal severity in mice
000002164 260__ $$bOregon Health and Science University
000002164 269__ $$a2006
000002164 336__ $$aThesis
000002164 502__ $$bM.S.
000002164 502__ $$gBehavioral & Systems Neuroscience
000002164 520__ $$aAllopregnanolone (ALLO) modulates GABAA_AA​ receptors and influences ethanol (EtOH) withdrawal. This study examined sex- and strain-dependent effects of finasteride, an ALLO synthesis inhibitor, on acute EtOH withdrawal while minimizing metabolic interactions. Male and female C57BL/6J and DBA/2J mice received finasteride or vehicle prior to acute EtOH exposure, and withdrawal severity was assessed using handling-induced convulsions. Finasteride increased withdrawal severity in females but decreased severity in males, without altering EtOH pharmacokinetics or hormone levels. These findings suggest sex-specific sensitivity to neurosteroid modulation during acute EtOH withdrawal.
000002164 540__ $$fCC BY
000002164 542__ $$fIn copyright - single owner
000002164 650__ $$aPregnanolone$$024553
000002164 650__ $$aAlcohol Withdrawal Seizures$$032282
000002164 650__ $$aFinasteride$$030525
000002164 650__ $$aSex Factors$$025927
000002164 691__ $$aSchool of Medicine$$041369
000002164 692__ $$aDepartment of Behavioral Neuroscience$$041394
000002164 7001_ $$aGorin-Meyer, Rebecca$$uOregon Health and Science University$$041354
000002164 7201_ $$aFinn, Deborah$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002164 8564_ $$9d641c5eb-9054-4742-9d02-9a0e45045376$$s1737071$$uhttps://digitalcollections.ohsu.edu/record/2164/files/2893_etd.pdf$$ePublic$$21cfd742225db803d0113a526610eec7f$$31
000002164 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002164 905__ $$a/rest/prod/5q/47/rn/98/5q47rn983
000002164 909CO $$ooai:digitalcollections.ohsu.edu:2164$$pstudent-work
000002164 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002164 980__ $$aTheses and Dissertations