000002179 001__ 2179
000002179 005__ 20260428075459.0
000002179 0247_ $$2DOI$$a10.6083/M48P5XSK
000002179 037__ $$aETD
000002179 245__ $$aThe selective translocation of the molecular motor Kinesin-1 during the development of neuronal polarity in culture
000002179 260__ $$bOregon Health and Science University
000002179 269__ $$a2006
000002179 336__ $$aDissertation
000002179 502__ $$bPh.D.
000002179 502__ $$gPhysiology & Pharmacology (sunsetting)
000002179 520__ $$aNeurons depend on intracellular transport to establish the distinct identities of axons and dendrites, yet how cargo is targeted to specific compartments remains unclear. This dissertation examines whether kinesin motor proteins preferentially translocate along distinct subsets of microtubules in cultured hippocampal neurons. Using constitutively active, fluorescently tagged kinesins, the study compares Kif1A and Kif5C localization. While Kif1A accumulates in all neurites, Kif5C selectively localizes to axons, a preference lost with taxol treatment. These findings suggest kinesin‑specific microtubule tracks contribute to axonal specification and identify Kif5C as a novel marker of neuronal polarity.
000002179 540__ $$fCC BY
000002179 542__ $$fIn copyright - single owner
000002179 650__ $$aAxons$$015276
000002179 650__ $$aMolecular Motor Proteins$$032396
000002179 650__ $$aNeurons$$022858
000002179 650__ $$aAxonal Transport$$015277
000002179 650__ $$aMicrotubules$$022299
000002179 650__ $$aKinesins$$029209
000002179 691__ $$aSchool of Medicine$$041369
000002179 692__ $$aDepartment of Physiology and Pharmacology$$041442
000002179 7001_ $$aSelph, Catherine$$uOregon Health and Science University$$041354
000002179 8564_ $$96506d1c6-af5e-4cf1-900d-d2c2772c8832$$s2245523$$uhttps://digitalcollections.ohsu.edu/record/2179/files/2908_etd.pdf$$ePublic$$23d0e33682680c9680154c0d1f53be0d9$$31
000002179 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002179 905__ $$a/rest/prod/th/83/kz/56/th83kz56p
000002179 909CO $$ooai:digitalcollections.ohsu.edu:2179$$pstudent-work
000002179 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002179 980__ $$aTheses and Dissertations