000002180 001__ 2180
000002180 005__ 20260428173542.0
000002180 0247_ $$2DOI$$a10.6083/M44X562N
000002180 037__ $$aETD
000002180 245__ $$aRegulation of PACS-1-directed protein trafficking
000002180 260__ $$bOregon Health and Science University
000002180 269__ $$a2006
000002180 336__ $$aDissertation
000002180 502__ $$bPh.D.
000002180 502__ $$gNeuroscience
000002180 520__ $$aThe cation-independent mannose-6-phosphate receptor (CI-MPR) cycles between the trans-Golgi network and endosomes to mediate lysosomal hydrolase trafficking, a process regulated by the adaptor proteins GGA3 and PACS-1. Although both bind a CK2-phosphorylated acidic cluster motif on CI-MPR, they direct opposing sorting steps. This study identifies autoregulatory acidic cluster domains in PACS-1 and GGA3 that are differentially controlled by CK2 phosphorylation. PACS-1 links CK2 to GGA3, forming a complex that coordinates CI-MPR release, retrieval, and recycling. These findings reveal a CK2-driven phosphorylation cascade that orchestrates endosomal–Golgi protein trafficking.
000002180 540__ $$fCC BY
000002180 542__ $$fIn copyright - single owner
000002180 650__ $$aProtein Transport$$032875
000002180 650__ $$aPhosphorylation$$024067
000002180 650__ $$aReceptor, IGF Type 2$$030040
000002180 6531_ $$apacs1 protein
000002180 691__ $$aSchool of Medicine$$041369
000002180 692__ $$aVollum Institute$$041509
000002180 7001_ $$aScott, Gregory$$uOregon Health and Science University$$041354
000002180 7201_ $$aThomas, Gary$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000002180 8564_ $$95cb2a8d3-e456-41a9-9851-fe42a173c30b$$s5050553$$uhttps://digitalcollections.ohsu.edu/record/2180/files/2909_etd.pdf$$ePublic$$2446bd6439bd696bc6f662b0efe0d0b97$$31
000002180 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002180 905__ $$a/rest/prod/bz/60/cw/53/bz60cw536
000002180 909CO $$ooai:digitalcollections.ohsu.edu:2180$$pstudent-work
000002180 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002180 980__ $$aTheses and Dissertations