@article{ETD,
      recid = {2184},
      author = {Guire, Eric},
      title = {Cellular mechanisms of synaptic plasticity in hippocampal  area CA1},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2006},
      number = {ETD},
      abstract = {Long-term potentiation (LTP) relies on coordinated kinase  activity, including CaMKII and ERK, to regulate synaptic  strength through AMPA receptor function and trafficking.  This study investigated calcium-dependent ERK activation,  identifying the CaMKK/CaMKI pathway as a potential link  between NMDA receptor signaling and ERK during LTP.  Additionally, the role of small G-proteins, particularly  Rac1 and its effector WAVE-1, was examined in synaptic  plasticity and actin remodeling. Findings suggest that  WAVE-1 influences dendritic structure and a novel form of  synaptic regulation termed capacitative metaplasticity,  offering new insight into mechanisms underlying learning  and memory.},
      url = {http://digitalcollections.ohsu.edu/record/2184},
      doi = {https://doi.org/10.6083/M4MW2FDW},
}