000002188 001__ 2188
000002188 005__ 20260512145331.0
000002188 0247_ $$2DOI$$a10.6083/M43X84WD
000002188 037__ $$aETD
000002188 245__ $$aIs surgical menopause associated with an increased risk of fracture in elderly U.S. women?
000002188 260__ $$bOregon Health and Science University
000002188 269__ $$a2006
000002188 336__ $$aThesis
000002188 502__ $$bM.P.H.
000002188 520__ $$aOsteoporotic fractures represent a major public health burden, accounting for substantial morbidity, mortality, and healthcare costs among older women. This study evaluated whether surgical menopause is associated with a higher risk of postmenopausal osteoporotic fracture compared with natural menopause. Using 20 years of prospective data from 9,704 community-dwelling Caucasian women aged 65 years and older in the Study of Osteoporotic Fractures, women were categorized by menopausal status and followed for nontraumatic, nonvertebral fractures. Multivariable Cox proportional hazards models, stratified by oral estrogen use, were used to estimate fracture risk. Among women who had never used oral estrogen, surgical menopause was associated with a modestly increased risk of nonvertebral fracture compared with natural menopause (RR 1.23, 95% CI 1.04–1.45). However, surgical menopause was not associated with an increased risk of hip or wrist fracture. These findings suggest that surgical menopause does not increase the risk of the most clinically significant osteoporotic fractures, although a small increase in nonvertebral fracture risk may exist among women who have never used oral estrogen.
000002188 540__ $$fCC BY
000002188 542__ $$fIn copyright - single owner
000002188 650__ $$aEpidemiology$$018518
000002188 650__ $$aOvariectomy$$023387
000002188 650__ $$aMenopause$$022037
000002188 650__ $$aOsteoporosis$$023359
000002188 650__ $$aRisk Factors$$025522
000002188 650__ $$aHip Fractures$$020213
000002188 650__ $$aHysterectomy$$020608
000002188 650__ $$aProportional Hazards Models$$028820
000002188 650__ $$aProspective Studies$$024706
000002188 650__ $$aPostmenopause$$030170
000002188 650__ $$aOsteoporotic Fractures$$039374
000002188 650__ $$aAged$$014351
000002188 650__ $$aIndependent Living$$038889
000002188 691__ $$aSchool of Medicine$$041369
000002188 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000002188 7001_ $$aVesco, Kimberly$$uOregon Health and Science University$$041354
000002188 8564_ $$9a5f26f17-a7e5-43b2-bc6d-e3c3a7e3c92c$$s665402$$uhttps://digitalcollections.ohsu.edu/record/2188/files/2917_etd.pdf$$ePublic$$2f23e1fb5db84247947ea6c08ee8c35f9$$31
000002188 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002188 905__ $$a/rest/prod/5q/47/rn/99/5q47rn99c
000002188 909CO $$ooai:digitalcollections.ohsu.edu:2188$$pstudent-work
000002188 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002188 980__ $$aTheses and Dissertations