TY  - GEN
AB  - Acute cocaine exposure produces lasting changes in striatal plasticity, but its long‑term effects on glutamate signaling remain unclear. This study examined time‑dependent changes in extracellular glutamate in the rat dorsolateral striatum following a single cocaine injection. In vivo microdialysis revealed a biphasic response, with glutamate levels increasing one day after cocaine exposure and decreasing three and fourteen days later. Mechanistic studies indicate that the initial increase depends on thalamocortical input and is associated with reduced astrocytic markers and glutamate transporter expression, while the later decrease involves altered glutamate transporter activity. These findings demonstrate that a single cocaine exposure causes long‑lasting, pathway‑dependent alterations in striatal glutamate regulation.
AD  - Oregon Health and Science University
AU  - McKee, Brenda
DA  - 2006
DO  - 10.6083/M4G73BZD
DO  - DOI
ED  - Meshul, Charlie
ED  - Mentor
ID  - 2193
KW  - Physiology
KW  - Dopamine
KW  - Rats
KW  - Glutamic Acid
KW  - Cocaine
KW  - Basal Ganglia
KW  - Pharmacology
KW  - Rats, Sprague-Dawley
KW  - Physiological Effects of Drugs
L1  - https://digitalcollections.ohsu.edu/record/2193/files/2922_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2193/files/2922_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2193/files/2922_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2193/files/2922_etd.pdf
N2  - Acute cocaine exposure produces lasting changes in striatal plasticity, but its long‑term effects on glutamate signaling remain unclear. This study examined time‑dependent changes in extracellular glutamate in the rat dorsolateral striatum following a single cocaine injection. In vivo microdialysis revealed a biphasic response, with glutamate levels increasing one day after cocaine exposure and decreasing three and fourteen days later. Mechanistic studies indicate that the initial increase depends on thalamocortical input and is associated with reduced astrocytic markers and glutamate transporter expression, while the later decrease involves altered glutamate transporter activity. These findings demonstrate that a single cocaine exposure causes long‑lasting, pathway‑dependent alterations in striatal glutamate regulation.
PB  - Oregon Health and Science University
PY  - 2006
T1  - The effects of cocaine on the dorsolateral striatum of the rat
TI  - The effects of cocaine on the dorsolateral striatum of the rat
UR  - https://digitalcollections.ohsu.edu/record/2193/files/2922_etd.pdf
Y1  - 2006
ER  -