000002193 001__ 2193
000002193 005__ 20260428120254.0
000002193 0247_ $$2DOI$$a10.6083/M4G73BZD
000002193 037__ $$aETD
000002193 245__ $$aThe effects of cocaine on the dorsolateral striatum of the rat
000002193 260__ $$bOregon Health and Science University
000002193 269__ $$a2006
000002193 336__ $$aDissertation
000002193 502__ $$bPh.D.
000002193 502__ $$gBiomedical Sciences
000002193 520__ $$aAcute cocaine exposure produces lasting changes in striatal plasticity, but its long‑term effects on glutamate signaling remain unclear. This study examined time‑dependent changes in extracellular glutamate in the rat dorsolateral striatum following a single cocaine injection. In vivo microdialysis revealed a biphasic response, with glutamate levels increasing one day after cocaine exposure and decreasing three and fourteen days later. Mechanistic studies indicate that the initial increase depends on thalamocortical input and is associated with reduced astrocytic markers and glutamate transporter expression, while the later decrease involves altered glutamate transporter activity. These findings demonstrate that a single cocaine exposure causes long‑lasting, pathway‑dependent alterations in striatal glutamate regulation.
000002193 540__ $$fCC BY
000002193 542__ $$fIn copyright - single owner
000002193 650__ $$aPhysiology$$024123
000002193 650__ $$aDopamine$$018026
000002193 650__ $$aRats$$036844
000002193 650__ $$aGlutamic Acid$$031020
000002193 650__ $$aCocaine$$016839
000002193 650__ $$aBasal Ganglia$$015374
000002193 650__ $$aPharmacology$$023909
000002193 650__ $$aRats, Sprague-Dawley$$029776
000002193 650__ $$aPhysiological Effects of Drugs$$035654
000002193 691__ $$aSchool of Medicine$$041369
000002193 7001_ $$aMcKee, Brenda$$uOregon Health and Science University$$041354
000002193 7201_ $$aMeshul, Charlie$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000002193 8564_ $$90cc094cf-2967-43e4-8f48-c4286dee1394$$s4261413$$uhttps://digitalcollections.ohsu.edu/record/2193/files/2922_etd.pdf$$ePublic$$290fae8dbed32b65936f1ae8ff77ea9b3$$31
000002193 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002193 905__ $$a/rest/prod/sx/61/dm/47/sx61dm473
000002193 909CO $$ooai:digitalcollections.ohsu.edu:2193$$pstudent-work
000002193 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002193 980__ $$aTheses and Dissertations