TY  - GEN
AB  - This dissertation investigates the relationship between structure and function of ATP‑sensitive potassium (KATP) channels in pancreatic cells. Mutations in KATP channel proteins can disrupt normal channel activity by altering gating or trafficking mechanisms. By examining the molecular effects of these mutations, this work advances understanding of how KATP channel structure governs function. These insights contribute to a clearer understanding of islet dysfunction and may support the development of targeted therapies aimed at improving KATP channel regulation.
AD  - Oregon Health and Science University
AU  - Lin, Yuwen
DA  - 2006
DO  - 10.6083/M4F769T1
DO  - DOI
ED  - Shyng, Show-Ling
ED  - Advisor
ID  - 2201
KW  - Ion Channel Gating
KW  - Structure-Activity Relationship
KW  - Diabetes Mellitus, Type 2
KW  - Physiology
KW  - Genetics
KW  - Adenosine Triphosphate
KW  - Potassium Channels
KW  - physiopathology
L1  - https://digitalcollections.ohsu.edu/record/2201/files/2930_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2201/files/2930_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2201/files/2930_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2201/files/2930_etd.pdf
N2  - This dissertation investigates the relationship between structure and function of ATP‑sensitive potassium (KATP) channels in pancreatic cells. Mutations in KATP channel proteins can disrupt normal channel activity by altering gating or trafficking mechanisms. By examining the molecular effects of these mutations, this work advances understanding of how KATP channel structure governs function. These insights contribute to a clearer understanding of islet dysfunction and may support the development of targeted therapies aimed at improving KATP channel regulation.
PB  - Oregon Health and Science University
PY  - 2006
T1  - Structure-function analysis of pancreatic ATP-sensitive potassium channels
TI  - Structure-function analysis of pancreatic ATP-sensitive potassium channels
UR  - https://digitalcollections.ohsu.edu/record/2201/files/2930_etd.pdf
Y1  - 2006
ER  -