000002201 001__ 2201
000002201 005__ 20260428123204.0
000002201 0247_ $$2DOI$$a10.6083/M4F769T1
000002201 037__ $$aETD
000002201 245__ $$aStructure-function analysis of pancreatic ATP-sensitive potassium channels
000002201 260__ $$bOregon Health and Science University
000002201 269__ $$a2006
000002201 336__ $$aDissertation
000002201 502__ $$bPh.D.
000002201 502__ $$gPhysiology & Pharmacology (sunsetting)
000002201 520__ $$aThis dissertation investigates the relationship between structure and function of ATP‑sensitive potassium (KATP) channels in pancreatic cells. Mutations in KATP channel proteins can disrupt normal channel activity by altering gating or trafficking mechanisms. By examining the molecular effects of these mutations, this work advances understanding of how KATP channel structure governs function. These insights contribute to a clearer understanding of islet dysfunction and may support the development of targeted therapies aimed at improving KATP channel regulation.
000002201 540__ $$fCC BY
000002201 542__ $$fIn copyright - single owner
000002201 650__ $$aIon Channel Gating$$028538
000002201 650__ $$aStructure-Activity Relationship$$026484
000002201 650__ $$aDiabetes Mellitus, Type 2$$017675
000002201 650__ $$aPhysiology$$024123
000002201 650__ $$aGenetics$$019472
000002201 650__ $$aAdenosine Triphosphate$$014248
000002201 650__ $$aPotassium Channels$$028230
000002201 6531_ $$aphysiopathology
000002201 691__ $$aSchool of Medicine$$041369
000002201 692__ $$aDepartment of Physiology and Pharmacology$$041442
000002201 7001_ $$aLin, Yuwen$$uOregon Health and Science University$$041354
000002201 7201_ $$aShyng, Show-Ling$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002201 8564_ $$95c7d3229-ab46-4c40-a1bb-cf0bebb276c3$$s4966080$$uhttps://digitalcollections.ohsu.edu/record/2201/files/2930_etd.pdf$$ePublic$$2c208d1e5df59ee27ab9be45c2a044831$$31
000002201 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002201 905__ $$a/rest/prod/p8/41/8n/42/p8418n42m
000002201 909CO $$ooai:digitalcollections.ohsu.edu:2201$$pstudent-work
000002201 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002201 980__ $$aTheses and Dissertations