TY  - GEN
AB  - Pregnancy is associated with reduced baroreflex gain, but its underlying mechanism remains uncertain. This study investigated the roles of nitric oxide, angiotensin II, and insulin resistance in this impairment using a rabbit model. Nitric oxide and angiotensin II were found not to influence baroreflex gain, as blockade of these pathways had no effect. In contrast, insulin resistance strongly correlated with reduced baroreflex function, with parallel declines during pregnancy and reversal following treatment with an insulin-sensitizing agent. Reduced insulin levels in cerebrospinal fluid further supported this link, suggesting that impaired insulin signaling contributes to decreased baroreflex gain in pregnancy.
AD  - Oregon Health and Science University
AU  - Daubert, Daisy
DA  - 2006
DO  - 10.6083/M4SJ1HV8
DO  - DOI
ED  - Brooks, Virginia
ED  - Advisor
ID  - 2206
KW  - Insulin Resistance
KW  - Angiotensin II
KW  - Pregnancy
KW  - Baroreflex
KW  - Nitric Oxide
KW  - Physiology
KW  - Rabbits
L1  - https://digitalcollections.ohsu.edu/record/2206/files/2935_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2206/files/2935_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2206/files/2935_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2206/files/2935_etd.pdf
N2  - Pregnancy is associated with reduced baroreflex gain, but its underlying mechanism remains uncertain. This study investigated the roles of nitric oxide, angiotensin II, and insulin resistance in this impairment using a rabbit model. Nitric oxide and angiotensin II were found not to influence baroreflex gain, as blockade of these pathways had no effect. In contrast, insulin resistance strongly correlated with reduced baroreflex function, with parallel declines during pregnancy and reversal following treatment with an insulin-sensitizing agent. Reduced insulin levels in cerebrospinal fluid further supported this link, suggesting that impaired insulin signaling contributes to decreased baroreflex gain in pregnancy.
PB  - Oregon Health and Science University
PY  - 2006
T1  - Decreased baroreflex gain during pregnancy: role of angiotensin II, nitric oxide and insulin sensitivity
TI  - Decreased baroreflex gain during pregnancy: role of angiotensin II, nitric oxide and insulin sensitivity
UR  - https://digitalcollections.ohsu.edu/record/2206/files/2935_etd.pdf
Y1  - 2006
ER  -