@article{ETD,
      recid = {258},
      author = {Gareau, Daniel},
      title = {In vivo confocal microscopy in turbid media},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2006},
      number = {ETD},
      abstract = {This dissertation describes the development and  application of a combined fluorescence and reflectance  confocal microscope for in vivo cancer detection in mice  through quantitative skin reflectance imaging. A novel  pinhole/ring detection scheme was introduced to suppress  diffuse light when imaging deep within scattering tissue,  improving axial resolution by 31% compared with  conventional pinhole detection. A calibration method was  developed to quantify tissue reflectance relative to a  mirror reference, enabling comparison across tissue types  and depth. Subsurface reflectance signals exhibited  exponential depth dependence, allowing derivation of  optical scattering properties, including scattering  coefficient (μs) and anisotropy (g), which effectively  differentiated most tissue types. Using these techniques,  reflectance confocal microscopy successfully imaged the  initiation and progression of malignant melanoma in vivo,  revealing characteristic features such as pagetoid  melanocytes, tumor nests, and disruption of the  dermal–epidermal junction.},
      url = {http://digitalcollections.ohsu.edu/record/258},
      doi = {https://doi.org/10.6083/M4NG4NJ3},
}