000002696 001__ 2696
000002696 005__ 20260120144901.0
000002696 0247_ $$2DOI$$a10.6083/M4TQ5ZV6
000002696 037__ $$aETD
000002696 245__ $$aThe role of ethanol and neuroanatomical regions in sensitivity to delay and sensitivity to magnitude of reward
000002696 269__ $$a2014
000002696 336__ $$aDissertation
000002696 502__ $$bPh.D.
000002696 502__ $$gBehavioral & Systems Neuroscience
000002696 520__ $$aDelay discounting—the preference for smaller, sooner rewards over larger, later ones—is increased by acute ethanol, but the underlying mechanisms remain unclear. This dissertation used two behavioral tasks in male Long Evans rats to separately assess sensitivity to delay and magnitude, and examined the effects of ethanol and temporary inactivation of the nucleus accumbens core (AcbC) and lateral orbitofrontal cortex (lOFC). Neither ethanol nor brain region inactivation altered sensitivity to delay or magnitude, but AcbC inactivation significantly reduced delay discounting, particularly in rats with low baseline discounting. Findings reveal task differences, a potential link between delay sensitivity and ethanol’s behavioral effects, and a novel role for AcbC in regulating impulsive choice.
000002696 540__ $$fCC BY
000002696 542__ $$fIn copyright - single owner
000002696 650__ $$aImpulsive Behavior$$020731
000002696 650__ $$aEthanol$$014406
000002696 650__ $$aReward$$025422
000002696 650__ $$aDelay Discounting$$040692
000002696 650__ $$aRats, Long-Evans$$032320
000002696 691__ $$aSchool of Medicine$$041369
000002696 692__ $$aDepartment of Behavioral Neuroscience$$041394
000002696 7001_ $$aMoschak, Travis$$uOregon Health and Science University$$041354
000002696 7201_ $$aMitchell, Suzanne$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002696 8564_ $$9c065a7a9-3333-4815-96a5-262aa80f8373$$s1841762$$uhttps://digitalcollections.ohsu.edu/record/2696/files/3493_etd.pdf$$ePublic$$211b2232c7af03e4135f72b296ee7472c$$31
000002696 905__ $$a/rest/prod/25/14/nk/77/2514nk77g
000002696 909CO $$ooai:digitalcollections.ohsu.edu:2696$$pstudent-work
000002696 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002696 980__ $$aTheses and Dissertations