000002701 001__ 2701
000002701 005__ 20260120144901.0
000002701 0247_ $$2DOI$$a10.6083/M4610XP5
000002701 037__ $$aETD
000002701 245__ $$aThe role of chondroitin sulfate proteoglycans and protein tyrosine phosphatase sigma in sympathetic nerve remodeling and arrythmia susceptibility after myocardial infarction
000002701 260__ $$bOregon Health and Science University
000002701 269__ $$a2014
000002701 336__ $$aDissertation
000002701 502__ $$bPh.D.
000002701 502__ $$gNeuroscience
000002701 520__ $$aSympathetic denervation following ischemia-reperfusion (I-R) injury is a strong predictor of arrhythmias and sudden cardiac death, yet the underlying mechanisms remain unclear. This study identifies chondroitin sulfate proteoglycans (CSPGs) in the infarcted myocardium as inhibitors of sympathetic axon regeneration and demonstrates that loss or pharmacologic inhibition of their receptor, PTPσ, restores sympathetic innervation. Reinnervation markedly reduced arrhythmia susceptibility and prevented electrophysiological remodeling, including Ca²⁺ mishandling, as shown by optical mapping. These findings reveal sympathetic reinnervation as protective post-I-R and establish PTPσ as a promising therapeutic target to prevent arrhythmias after myocardial infarction.
000002701 540__ $$fCC BY
000002701 542__ $$fIn copyright - single owner
000002701 650__ $$aProtein Tyrosine Phosphatases$$029630
000002701 650__ $$aChondroitin Sulfate Proteoglycans$$024765
000002701 650__ $$aMyocardial Infarction$$022601
000002701 650__ $$aSympathetic Nervous System$$026699
000002701 650__ $$aArrhythmias, Cardiac$$015069
000002701 691__ $$aSchool of Medicine$$041369
000002701 692__ $$aVollum Institute$$041509
000002701 7001_ $$aGardner, Ryan$$uOregon Health and Science University$$041354
000002701 7201_ $$aHabecker, Beth$$uOregon Health and Science University$$041354$$7Personal$$eMentor$$eAdvisor
000002701 8564_ $$90457f503-cad1-4e5f-8909-c3bb78468641$$s9337111$$uhttps://digitalcollections.ohsu.edu/record/2701/files/3488_etd.pdf$$ePublic$$2075c88f0cd1a85b441f7f03ff8abcc45$$31
000002701 905__ $$a/rest/prod/0k/22/5b/31/0k225b31k
000002701 909CO $$ooai:digitalcollections.ohsu.edu:2701$$pstudent-work
000002701 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002701 980__ $$aTheses and Dissertations