000002712 001__ 2712
000002712 005__ 20251208154124.0
000002712 0247_ $$2DOI$$a10.6083/M4RR1WJJ
000002712 037__ $$aETD
000002712 245__ $$aThe β subunit of the AP-1 complex is essential for hair cell function and basolateral targeting of NKA
000002712 260__ $$bOregon Health and Science University
000002712 269__ $$a2013
000002712 336__ $$aDissertation
000002712 502__ $$bPh.D.
000002712 520__ $$aMechanosensation in hair cells relies on precise protein trafficking and specialized structures for proper function. Using zebrafish models, this work examines the role of adaptor protein 1 beta 1 (ap1b1) in mechanotransduction and ion regulation, showing that ap1b1 mutations mislocalize Na⁺/K⁺ ATPase and disrupt intracellular Na⁺ homeostasis. Additionally, we identify tmhsa and Tmc2a as key contributors to mechanotransduction. Tmhsa localizes to stereocilia tips and rescues auditory and vestibular defects in mutants, while Tmc2a modulates mechanosensitivity through distinct N- and C-terminal domains. These findings reveal critical mechanisms underlying hair-cell function and sensory system development.
000002712 540__ $$fCC BY
000002712 542__ $$fIn copyright - single owner
000002712 650__ $$aZebrafish Proteins$$033767
000002712 650__ $$aZebrafish$$028076
000002712 650__ $$aProtein Transport$$032875
000002712 650__ $$aHair Cells, Auditory$$019810
000002712 650__ $$aHair Cells, Vestibular$$030477
000002712 650__ $$aMechanotransduction, Cellular$$035047
000002712 6531_ $$azebra danio
000002712 691__ $$aSchool of Medicine$$041369
000002712 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000002712 7001_ $$aClemens Grisham, Rachel$$uOregon Health and Science University$$041354
000002712 8564_ $$95180256b-3ac3-4643-b620-e6c6b76eb35e$$s3417547$$uhttps://digitalcollections.ohsu.edu/record/2712/files/3477_etd.pdf$$ePublic$$2e7a98c634aeb206e0f598724be079ffd$$31
000002712 905__ $$a/rest/prod/dr/26/xx/56/dr26xx562
000002712 909CO $$ooai:digitalcollections.ohsu.edu:2712$$pstudent-work
000002712 980__ $$aTheses and Dissertations