000002719 001__ 2719
000002719 005__ 20251208124713.0
000002719 0247_ $$2DOI$$a10.6083/M4VH5M4W
000002719 037__ $$aETD
000002719 245__ $$aRegulation of cell shape during development of the nervous system
000002719 260__ $$bOregon Health and Science University
000002719 269__ $$a2013
000002719 336__ $$aDissertation
000002719 502__ $$bPh.D.
000002719 502__ $$gNeuroscience
000002719 520__ $$aProper sensory system function requires coordinated development of neurons and their target organs, involving dramatic cell shape changes. Using zebrafish, this study investigates molecular signals driving these processes in the posterior lateral line (pLL), a mechanosensory system. We identify a novel role for Fibroblast Growth Factor (Fgf) in regulating apical constriction via Rho-kinase 2a during rosette formation, essential for neuromast development. Concurrently, we show that JNK-interacting protein 3 (Jip3) mediates axonal outgrowth by enabling Ret receptor transport in afferent neurons. These findings reveal distinct signaling pathways controlling morphogenesis of sensory organs and neurons, advancing understanding of vertebrate sensory development.
000002719 540__ $$fCC BY
000002719 542__ $$fIn copyright - single owner
000002719 650__ $$aLateral Line System$$037373
000002719 650__ $$aDevelopmental Biology$$028463
000002719 650__ $$aZebrafish$$028076
000002719 650__ $$aGrowth and Development$$036136
000002719 650__ $$aNervous System$$022807
000002719 650__ $$aFibroblast Growth Factors$$019019
000002719 650__ $$aNeurons$$022858
000002719 650__ $$aSense Organs$$025870
000002719 6531_ $$alateral line organs
000002719 6531_ $$azebra danio
000002719 691__ $$aSchool of Medicine$$041369
000002719 692__ $$aVollum Institute$$041509
000002719 7001_ $$aHarding, Molly$$uOregon Health and Science University$$041354
000002719 7201_ $$aNechiporuk, Alex$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002719 8564_ $$9642aafc1-bad5-4162-a818-cf14afe1803d$$s102890621$$uhttps://digitalcollections.ohsu.edu/record/2719/files/3470_etd.pdf$$ePublic$$2694b11edaffed050cc95dec04c3f8e3b$$31
000002719 905__ $$a/rest/prod/70/79/57/96/70795796b
000002719 909CO $$ooai:digitalcollections.ohsu.edu:2719$$pstudent-work
000002719 980__ $$aTheses and Dissertations