000002722 001__ 2722
000002722 005__ 20260120144901.0
000002722 0247_ $$2DOI$$a10.6083/M4GB22DK
000002722 037__ $$aETD
000002722 245__ $$aTransplantation of differentiated iPSCs as a treatment strategy for glaucoma
000002722 260__ $$bOregon Health and Science University
000002722 269__ $$a2013
000002722 336__ $$aDissertation
000002722 502__ $$bPh.D.
000002722 502__ $$gBiochemistry & Molecular Biology (sunsetting)
000002722 520__ $$aCompromised regulation of intraocular pressure (IOP) is the primary risk factor for primary open-angle glaucoma (POAG), characterized by trabecular meshwork (TM) cell loss. To model this, we created partially denuded TM areas and developed transplantable TM-like cells from induced pluripotent stem cells (iPSCs). These cells were tested in an ex vivo perfusion system for two key TM functions: IOP homeostasis and phagocytosis. Transplanted TM-like cells integrated into TM tissue and restored pressure regulation under high IOP challenge, while exhibiting phagocytic activity comparable to native TM cells. This approach demonstrates a novel strategy for TM cell replacement and glaucoma treatment.
000002722 540__ $$fCC BY
000002722 542__ $$fIn copyright - single owner
000002722 650__ $$aInduced Pluripotent Stem Cells$$038800
000002722 650__ $$aGlaucoma$$019541
000002722 650__ $$aStem Cells$$026391
000002722 650__ $$aTrabecular Meshwork$$027228
000002722 650__ $$aIntraocular Pressure$$020970
000002722 650__ $$aAntiglaucoma Agents$$013659
000002722 650__ $$aGlaucoma, Open-Angle$$019542
000002722 650__ $$aRisk Factors$$025522
000002722 691__ $$aSchool of Medicine$$041369
000002722 692__ $$aDepartment of Biochemistry and Molecular Biology$$041396
000002722 7001_ $$aAbu-Hassan, Diala$$uOregon Health and Science University$$041354
000002722 7201_ $$aAcott, Ted$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002722 8564_ $$95279ec5d-dbd1-4cee-abfa-bd0fcb8a45f0$$s3985587$$uhttps://digitalcollections.ohsu.edu/record/2722/files/3467_etd.pdf$$ePublic$$2db9bb9ca7fc4a7031abcaea318272362$$31
000002722 905__ $$a/rest/prod/tm/70/mv/34/tm70mv34w
000002722 909CO $$ooai:digitalcollections.ohsu.edu:2722$$pstudent-work
000002722 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002722 980__ $$aTheses and Dissertations